You have entered an incorrect email address! Please enter your email address here Decision Apopka 2018:Northwest Recreation Complex joins Apopka Community Center as voting sitesThe VOICE of Local ElectionsThe Apopka City Council voted 5-0 last night to open a second voting precinct for the General Election on March 13th, 2018.According to the Agenda Packet provided by the City for last night’s meeting, the clerks office budgeted for two precincts, and was approved in the fiscal year 2017-18 budget. It also states that the City Clerk’s office has had multiple complaints in the past that there is only one polling place in previous General Elections.The two precinct locations for the 2018 election will be the VFW/Apopka Community Center, located at 519 South Central Avenue and the Northwest Recreation Complex Conference Room (3710 Jason Dwelley Parkway). Electors will receive an informational voter card with their precinct listed.Early Voting remains at the Orange County Supervisor of Elections office at 119 West Kaley Street in Orlando. Voters may also request a vote-by-mail ballot through the Supervisor. For more details, go here.There are three elections on the 2018 ballot – Apopka Mayor, City Commission Seats #1 and #2.Incumbent Apopka Mayor Joe Kilsheimer is being challenged by Orange County Commissioner Bryan Nelson in the 2018 Mayoral race.In the seat #1 election, Suzanne Kidd, Gene Knight, Theresa Mott, and Alexander Smith are running to succeed retiring City Commissioner Billie Dean. In Seat #2, incumbent Commissioner Diane Velazquez is currently running unopposed.In the 2014 Apopka elections, 4,961 voters turned-out in the March 11th General Election, while 6,664 voted in the April 8th runoff.In 2016 10,374 turned-out in the March 15th General Election (which was enhanced by multiple voting precincts and presidential candidates also on the ballot in the Florida Primary), while 4,930 voted in the April 12th runoff, which had only one voting site.According to the City’s Public Information Office, it has not been determined if there will be a second polling place in the event of a runoff, which takes place in the event no candidate receives a majority of the votes in the General Election. October 20, 2017 at 12:20 pm TAGSDecision Apopka 2018Northwest Recreation ComplexVFW Apopka Community Center Previous articleOrange County closing Zellwood debris drop-off siteNext articleCookies and Milk with a Cop coming this weekend Denise Connell RELATED ARTICLESMORE FROM AUTHOR Free webinar for job seekers on best interview answers, hosted by Goodwill June 11 I am not familiar with the Northwest Recreation Complex Conference Room. I don’t know where it is, other than out at NW complex. I have voted in a lot of different sites however. I have voted at the Methodist church on Park Avenue, the VFW/Community Center, the Apopka High, the Baptist church on Welch, the Baptist church right before Rock Springs, the Orange County Service Building on RSR, and even the library on 436, for a presidential election one year, and that one was the worst location of all, as it was a very long line that snaked around the building in the hot sun, and it was hours before I got to vote, plus virtually no parking spaces, as they were all took up by the people going to the library. The voters parked at 7-11, and got yelled at, at the auto parts store, the same, and down the side of Thompson Road, and even parked into the subdivision along the roadside in there where the homes were. Who made that decision to have a presidential election voter precinct at the library on 436 that doesn’t truly have enough parking for the customers, as it is now? 1 COMMENT Share on Facebook Tweet on Twitter Reply LEAVE A REPLY Cancel reply Please enter your name here The Anatomy of Fear Please enter your comment! Support conservation and fish with NEW Florida specialty license plate Mama Mia Save my name, email, and website in this browser for the next time I comment.
A gene therapy that delivers a protein that suppresses the development of female reproductive organs may improve survival rates in patients with ovarian cancer that has recurred after chemotherapy. Recurrence happens 70 percent of the time and is invariably fatal.In their report receiving online publication in PNAS Early Edition, a research team from Harvard-affiliated Massachusetts General Hospital (MGH) describes how a single injection of a modified version of Mullerian inhibiting substance (MIS), a protein critical to sexual development, suppressed the growth of chemotherapy-resistant ovarian tumors in a mouse model. While not all the tested tumors — grown from cells grafted from patient tumors — were sensitive to this treatment, the investigators also outlined a noninvasive way of screening cancer cells in vitro for treatment responsiveness.“Our findings are important because there are currently no therapeutic options for recurrent, chemoresistant ovarian cancer,” said Harvard Medical School (HMS) instructor in surgery David Pepin of the MGH Pediatric Surgical Research Laboratories. Pepin is the lead author of the report. “This is also a proof of concept that gene therapies with the AAV9 vector can be used to deliver biologics for the treatment of ovarian cancer, and represents the first time this approach has been tested in this type of ovarian cancer model.” During embryonic development, MIS is secreted by tissues in male embryos to prevent maturation of the Mullerian duct, which otherwise would give rise to female reproductive organs. The potential of MIS to treat ovarian cancer and other reproductive tumors has been studied for many years by Patricia Donahoe, director of the MGH Pediatric Surgical Research Laboratories and senior author of the study. Previous investigations by Donahoe’s team have shown that MIS suppresses ovarian cancer growth, both in animals and in human cell lines, by targeting the cancer stem cells that survive chemotherapy; but previous methods of producing MIS were unable to generate sufficient quantities of high-quality protein for preclinical testing.The current study employed a modified form of the MIS gene, developed by Pepin to generate protein of greater purity and effectiveness, combined with the accepted viral vector AAV9 for delivery into the peritoneal cavity, a common site for the recurrence of ovarian cancer. The modified MIS/AAV9 construct was tested against tumor cells taken from ascites fluid that had accumulated in the abdomens of several patients with recurrent ovarian cancer. Initial experiments confirmed that these cells expressed the MIS receptor protein, carried markers indicating their identity as cancer stem cells, and that their growth was inhibited in vitro by MIS. A single injection of the MIS/AAV9 construct into the peritoneal cavity of mice resulted in elevated expression of MIS by multiple tissues throughout the abdominal cavity and in adjacent muscles.The effectiveness of the MIS/AAV9 construct was tested in mice implanted with ovarian cancer cells. The test revealed that treatment with MIS/AAV9 three weeks prior to tumor implantation significantly inhibited tumor growth. In a more clinically relevant experiment, applying the therapy to mice in which tumors already had been induced by implanting cancer cells from five different patients significantly inhibited further growth of tumors generated from the cells of three of the five patients. Analysis of tumor samples from more than 200 patients revealed that 88 percent expressed some level of the MIS receptor, with 65 percent expressing moderate or high protein expression.“Since the response to MIS gene therapy is not the same for all patients, it will be important to first screen each patient’s tumors to ensure they will respond” said Pepin. “While we have not yet identified biomarkers of treatment response — something we are currently searching for — we have described a way to rapidly grow tumor cells from ascites to be evaluated for drug sensitivity. If further study confirms the susceptibility of chemoresistant tumors to this MIS gene therapy, the ability to inhibit tumor recurrence could significantly extend patient survival.”“All of the implanted tumor cells were from patients who failed all previous therapies, so a 60 percent response rate is quite significant for a single agent,” said Donahoe, who is the Bartlett Distinguished Professor of Surgery at HMS. “The ability to administer this MIS/AAV9 construct — prepared by Guangping Gao, director of the Gene Therapy Program at the University of Massachusetts and a long-term leader in the field of gene therapy — as a single, long-acting injection makes the use of this effective but complex protein both clinically feasible and patient-friendly. Our results provide proof of concept and predict a translation into patient care that was not previously possible.” The Daily Gazette Sign up for daily emails to get the latest Harvard news.
Pierluigi Collina visited Sarajevo on Wednesday, and ended up being pleasantly surprised by its beauty, buildings and night lights.In an interview, Collina revealed details of his visit to the capital of Bosnia and Herzegovina, and the legendary referee commented on today’s world of football as well.I am impressed by the beauty of Sarajevo, which is experience I was really waiting for. Yesterday I was in a restaurant overlooking the city, and night view on the Sarajevo is something really amazing. Unfortunately, I came yesterday and I have to go back today, “said Collina.His hosts made sure that Italian legend is not going back until he tries some of traditional Bosnian cuisine, which he was very satisfied with.“I tried baklava and prefer the Bosnian compared to a Turkish version, because it is less sweet. I tried grilled lamb and cheese pie in a restaurant that I mentioned before, and there is still a lot of things that I liked as well. As for the Bosnian cuisine I think I will enjoy the kebabs before I go back, since everyone is talking about them. Without trying them, I just cannot go back, “explained Collina.Collina is a member of the UEFA Referees Committee and the head of referees for the Football Federation of Ukraine.He also mentioned some of the best of Bosnian football referees who judge today under the auspices of UEFA, such as Irfan Peljto and Edin Jakupović who are working hard and, as Collina hopes, will become an important part of a large team of referees and the future of UEFA.(Source: klix/ photo thestar)