Gene network analyses support subfunctionalization hypothesis for duplicated hsp70 genes in the Antarctic clam

first_imgA computationally predicted gene regulatory network (GRN), generated from mantle-specific gene expression profiles in the Antarctic clam Laternula elliptica, was interrogated to test the regulation and interaction of duplicated inducible hsp70 paralogues. hsp70A and hsp70B were identified in the GRN with each paralogue falling into unique submodules that were linked together by a single shared second neighbour. Annotations associated with the clusters in each submodule suggested that hsp70A primarily shares regulatory relationships with genes encoding ribosomal proteins, where it may have a role in protecting the ribosome under stress. hsp70B, on the other hand, interacted with a suite of genes involved in signalling pathways, including four transcription factors, cellular response to stress and the cytoskeleton. Given the contrasting submodules and associated annotations of the two hsp70 paralogues, the GRN analysis suggests that each gene is carrying out additional separate functions, as well as being involved in the traditional chaperone heat stress response, and therefore supports the hypothesis that subfunctionalization has occurred after gene duplication. The GRN was specifically produced from experiments investigating biomineralization; however, this study shows the utility of such data for investigating multiple questions concerning gene duplications, interactions and putative functions in a non-model species.last_img read more

6 of the Best – KamaGames’ Sam Forrest

first_img Share Submit Share BGC – Scotland and Wales must come clear on casino reopenings July 28, 2020 Related Articles England’s casinos to reopen on 1 August July 17, 2020 This week’s 6 of the Best comes from Sam Forrest, Director of Global Communications and Content at KamaGames.Keep reading to find out more about South East Asian delights, a musical conundrum and betting regrets.Best HolidayI got to disappear for 4 weeks over last Christmas and visit South East Asia. I managed to get to Malaysia, Vietnam and Thailand with the highlight definitely being a tiny island between Malaysia and Thailand called Koh Lipe. A very chilled out spot with great diving and cold beer – what else could you need!? Wearing shoes upon my return was definitely a challenge as was dealing with going from a 30 degree to a -2 degree climate. Needless to say flights are already being researched for next Christmas although a couple of weeks on the Croatian islands between now and then would be a bonus!Best albumI honestly don’t have one as there are simply too many choices to pick. That said, a staple on vinyl, CD, MP3 and Spotify in one way or another over the years are Raising Hell by Run-DMC and Licenced to Ill by Beastie Boys.Best sporting experienceIt’s was definitely my first visit to Twickenham years ago to see England vs Scotland. Sadly, I don’t actually remember most of the game due to being in a “very sociable” section surrounded by gentlemen who insisted on sharing hipflasks, but needless to say it was a great day, with a great atmosphere… apparently.Best filmTricky as it really depends on mood. I am a real action and sci-fi fan so 13 Hours and BlackHawk Down are going to be up there but I think good old Alien is going to win this one.Best BookLightening by Dean Koontz, a fantastic book. I’ve acquired several copies over the years and normally have a copy with me when I am away on holiday. Oh and I also have a version on my phone just in case. After all, who doesn’t like time travelling Nazis.Best BetWell it should have been at this year’s Grand National with Ucello Conti at £100 to win which would have meant a rather pleasant rest of the weekend for yours truly. Then of course, the 3rd fence from the end changed a night at the Hawksmore to a night at AbraKebabra…. So, a great bet, but not a great result (these were not the calm words I chose to use at the time I hasten to add). StumbleUpon Scottish government lifts shop restrictions on bookmakers July 13, 2020last_img read more

Bolt has ‘touch like a trampoline’ – A-League striker

first_imgSydney, Australia | AFP | Former Ireland striker Andy Keogh blasted Usain Bolt as having “a touch like a trampoline” Friday as the coach of the Central Coast Mariners refused to say whether he believes the sprint star can make it as a footballer.Keogh, who plays for Perth Glory, said it would be a “kick in the teeth” to footballers if the eight-time Olympic champion earns a professional contract with Australia’s Mariners.The 32-year-old Jamaican, who retired from athletics last year, has been on trial with the A-League club since August but contract negotiations have stalled and he is no longer training.Sydney’s Daily Telegraph reported this week that Bolt’s representatives were initially seeking Aus$3 million (US$2.1 million) but the Mariners have offered closer to Aus$150,000.The Mariners have said it appears unlikely the Jamaican will sign unless a third-party agreement can be found to deliver him more money.Keogh, who used to play for Wolves and Cardiff, was blunt in his assessment of Bolt’s footballing prowess.He told Fox Sports the 100m world-record holder had a touch “like a trampoline” and that “he’s not going to be able to make it”.“It’s nice to have the attention on the A-League but him playing in the A-League, that’s not for me,” said Keogh, who made 30 appearances for his country. “He’s shown a bit (of potential) but it’s a little bit of a kick in the teeth to the professionals that are in the league.”He added that “if there’s someone who genuinely thinks he’d be a good football addition, I don’t think they should be in a position to make those calls”.Mariners boss Mike Mulvey was peppered with questions about Bolt at a press conference Friday, batting most of them away.“There’s no update. He’s not at training and I’m just concentrating on the lads I have here,” he said, insisting the Bolt saga was not a distraction.Pressed on whether Bolt had the ability to make it as a footballer, he replied: “I’ll say this one more time — my focus is on the game on Saturday and on the players contracted for the Central Coast Mariners and that is how it should be.”Bolt, who retired from athletics last year, has previously tried out with clubs in Germany, South Africa and Norway.He recently turned down a two-year, trial-free deal from cashed-up Maltese champions Valletta.Share on: WhatsApplast_img read more